New research suggests that individuals who stop using popular GLP-1 drugs like semaglutide or tirzepatide may regain reduced body mass much more quickly than those who stop traditional diet and exercise programs.
Findings released in a prominent medical journal shows that while overweight individuals often shed about a fifth of their total mass while on the medication, the mass comes back at an average rate of 0.8 kg per month once they quit.
"Users using such treatments need to be informed of the potential of fast rebound weight gain when the medication is stopped," warns researcher Dr. Susan Jebb.
Such speed of recovery means a reversion to pre-treatment mass within about one and a half years.
Comparing Approaches
The research, which examined 37 of studies involving over 9,000 of participants, contrasted the effects of the injectable medications with other pills.
Scientists note that people who lose weight through lifestyle changes alone usually have a more gradual weight regain—around 100 grams monthly—post-intervention.
Explaining the Rapid Regain
Experts suggest the mechanism of the jabs is key to understanding the heightened rebound.
GLP-1 drugs copy a body's own chemical called glucagon-like peptide-1, which controls appetite.
"Sustained high doses of the hormone levels far above than the body's typical production could lead to the body to produce less of its own natural hormone, and may also lessen responsiveness to its effects," explained Dr. Adam Collins, a dietetics researcher.
"Stopping of this GLP-1 'fix' results in appetite is uncontrolled, making excessive eating far more likely."
A Chronic Disease?
Health authorities advise the jabs for individuals with weight-linked medical conditions, accompanied by prescribed lifestyle changes.
Many experts argue that, given the significant potential of weight regain, the therapy might need to be life-long.
This view is reinforced by drug manufacturers, who say that the findings "underscore the chronic character of obesity," akin to managing conditions like high blood pressure.
Patient Accounts
Users who have come off the medication describe a sudden resurgence of hunger.
"I experienced a trigger flipping and I was suddenly extremely hungry," recalled a patient.
The struggle is exacerbated if users have not adopted sustainable lifestyle or habit changes during treatment.
Growing Interest
Figures show that a significant number of adults in the UK have used weight-loss jabs in the last 12 months, with demand being substantial.
- Use is more common among females than men.
- The 40s and 50s demographic shows the highest usage rates.
- Many access the medications through private healthcare rather than public health services.
In conclusion, experts emphasize that while the jabs are potent agents for shedding pounds, they are not a magic fix and long-term success likely depends on ongoing lifestyle support.
